STRUCTURAL CHANGES IN THE RAT TESTES CAUSED BY DIAZINON ADMINISTRATION
Keywords:
diazinon, testis, histology, morphometry, ratAbstract
The aim of this study was to find the structural changes in the rat testis after a
diazinon administration. The testis structure changes after the diazinon
administration of 20 mg/kg b.w. (i.p.) and daily dose of 40 mg/l in drinking water
(p.o.) were evaluated in light microscopy. 36 hours after the diazion i.p.
administration, the vacuolization of the seminiferous epithelium, evacuation of germ
cells into the tubule lumen, epithelium necrosis and interstitium extension were
observed. After 90 days of daily oral administration, the changes in the testis were
not as visible as in the acute intoxication. The germ cells released from the basal
lamina and then were visible in the tubule lumen. Diazinon causes the damage of the
germinal epithelium in the testes leading to the spermatogenesis failure. The
infertility can then appear.
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