ERYTHROCYTE MEMBRANE RESISTANCE IN ADULT FEMALE RATS EXPOSED TO POTASSIUM DICHROMATE (Cr VI) IN UTERO, DURING SUCKLING AND PRE-PUBERTY PERIOD
Keywords:
chromium dichromate, rats, membrane erythrocyteAbstract
The aim of the study was to relieve the impact of chromium hexavalent ions on the
resistance of erythrocyte membrane in female rats at sexual maturity but exposed
“in utero”or during the suckling or pre-puberty period. Concrete objectives were
to establish the effect of 25 ppm (E1 group), 50 ppm (E2 groupt) and 75 ppm (E3
group) chromium doses on haemoglobin (Hb) and erythrocyte membrane
resistance (R.O.) (in terms of haemolysis degree in NaCl hypotonic solutions). The
consequence of Cr(VI) exposure was the high significant decrease (p<0,01) of Hb
in all E groups compared to control (C) (E1/C:-24.66%; E2/C: - 37.36%; E3/C: -
42.67%), under physiologic limits in E2 and E3 groups and at the lowest
physiologic limit in E1. Maxim R.O. was equal in all groups and in physiologic
limits. Minim R.O. decreased to 0.7% NaCl in E1 and to 0.8% NaCl in E2 and E3.
It was asserted the increase of haemolyse degree in direct relation with the dose.
Increasing the chromium intake level a haemolytic effect was induced.
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